Intra Cytoplasmic Morphologically Selected Sperm Injection (IMSI) is a more sophisticated variation of ICSI.

During this process before injection,  your embryologist will observe the sperm, with a higher-powered microscope

, in greater detail for the integrity of its nucleus. The nucleus is a part of sperm containing all its genetic material. This technique enables a doctor to select better quality sperms which result in higher pregnancy rates and a lower number of miscarriages when compared with conventional ICSI.

The shape of the sperm (morphology) is vital in diagnosing male fertility problems and predicting fertilization and pregnancy outcomes. Many studies have shown that selecting better-shaped sperm does improve ICSI outcomes.

What is the difference between IMSI and ICSI?

In conventional ICSI, the embryologist uses a microscope to select the most healthy-looking sperm. This microscope can magnify the sample up to 400x.

IMSI on the other hand uses a high-power light microscope which magnifies the sample over 6000 times.

At this magnification, an embryologist can detect very fine structural changes in sperm that may remain undetected by a normal microscope.

The embryologist then selects a sperm with a most normally shaped nucleus.

IMSI could increase the chance of fertilization in case of various unsuccessful attempts of In Vitro Fertilization attempts.

What are the different conditions in which IMSI can be indicated?

The doctor can prescribe IMSI in case of the following conditions

• Sperm aneuploidy or presence of abnormal chromosomes in the sperm
• Severe oligozoospermia or very low sperm count
• Severe asthenozoospermia or severely reduced sperm motility
• Severe teratozoospermia or a very high quantity of abnormal sperms
• Multiple early abortions.
• History of miscarriages.
• History of ICSI failures.

What are the potential disadvantages of the IMSI procedure?

IMSI is a time-consuming procedure. The entire process of selecting the right sperm and discarding the wrong ones may last up to 5 hours.

Also, the procedure requires sophisticated microscopes which may not be present in all fertility centers.

Why choose Yana IVF for the IMSI procedure?

At Yana, we have the state-of-the-art infrastructure necessary to carry out IMSI successfully.

The IMSI procedure at Yana IVF is carried by a team of highly successful embryologists with great diligence leading to the success of the procedure as well as complete patient satisfaction.